Indeed, it is possible to change the location of the database folder, in the openLCA.ini (which is in the same folder as openLCA.exe):
The start could be
-nl
en
-olcaDataDir
C:\...the_new_path_to_the_database_folder
...
Make a backup of the file before, then edit and save it.
On a Mac, it should be the same. olcaDataDir needs to be written exactly as above.
Hth, Andreas